Progress Regarding Hypodiploid Acute Lymphoblastic Leukemia – “HALL”

 

In conjunction with Dr. Steven Hunger (Colorado Children’s Hospital and Chair of the ALL (Acute Lymphoblastic Leukemia) Committee of the Children’s Oncology Group*) and Dr. Charles Mullighan (St. Jude’s Research Hospital) and other members of the National Children’s Oncology Group, The Henry Schueler 41 & 9 Foundation helped sponsor the most comprehensive analysis of Hypodiploid ALL (“HALL”) ever performed. This type of ALL that Henry was afflicted with is extremely rare. In fact, only 124 samples of “HALL” are known to exist in the United States. Yet ALL is the most common form of pediatric leukemia and despite improvements in the outcome of therapy for ALL, this disease remains the most common cause of cancer-related death in young people.

Hypodiploid ALL or “HALL”, with fewer than 44 chromosomes is characterized by multiple whole-chromosomal losses and extremely poor outcomes. This project led to a gene analysis of samples from patients with three different forms of this rare leukemia to confirm genetic differences that could lead to new treatments.

Research led by St. Jude Children’s Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.

The findings also provide the first evidence of the genetic basis for this high-risk leukemia. Normal human cells have 46 chromosomes, half from each parent, but hypodiploid ALL is characterized by fewer than 44 chromosomes. Chromosomes are highly condensed pieces of DNA, the molecule that carries the inherited instructions for assembling and sustaining a person. The research appeared in the January 20, 2013 advance online edition of the scientific journal Nature Genetics.

The study, the largest ever focused on hypodiploid ALL, confirmed that this tumor has distinct subtypes distinguished by the number of chromosomes lost and the submicroscopic genetic alterations they harbor. Researchers found evidence suggesting more than one-third of patients with a subtype known as low hypodiploid ALL have Li-Fraumeni syndrome. Families with Li-Fraumeni syndrome harbor inherited mutations in the TP53 tumor suppressor gene and have a high risk of a range of cancers. Hypodiploid ALL had not previously been recognized as a common manifestation of Li-Fraumeni syndrome.

Significantly, researchers reported that the major hypodiploid subtypes are both sensitive to a family of compounds that block the proliferation of cancer cells. The compounds include drugs already used to treat other cancers. The subtypes are low hypodiploid ALL, characterized by 32 to 39 chromosomes, and near haploid ALL, which has 24 to 31 chromosomes.

“This study is a good example of the important insights that can be gained by studying the largest possible number of patients in as much detail as possible. This approach led us to key insights about these leukemia subtypes that we would otherwise have missed,” said the study’s senior and corresponding author, Charles Mullighan, MBBS(Hons), MSc, M.D., an associate member of the St. Jude Pathology Department. Mullighan is a Pew Scholar in Biomedical Sciences.

The near haploid and low hypodiploid ALL subtypes represent 1 to 2 percent of the estimated 3,000 pediatric ALL cases diagnosed annually in the U.S. But they account for a much larger number of ALL treatment failures. Today more than 90 percent of young ALL patients will become long-term survivors, compared to 40 percent for patients with these two high-risk subtypes. St. Jude researchers led the study in collaboration with investigators from the Children’s Oncology Group, the world’s largest organization devoted exclusively to childhood and adolescent cancer research.

Note the authors’ recognition of Hank’s living wish below:

“The cure rate for hypodiploid ALL is only about half that obtained overall for children with ALL. The findings of this study are very important and have the potential to impact how this high-risk subset of childhood ALL is treated,” said Stephen Hunger, M.D., chair of the Children’s Oncology Group ALL committee and one of the paper’s co-authors. “This study grew out of the efforts of Hank Schueler, a teenager who died from hypodiploid ALL. He wanted to find ways to help treat other children with this type of leukemia. After he passed away, his parents established a foundation to support research in hypodiploid ALL. We thought that one way to do this was to conduct the genomic analyses reported in this paper. These findings would not have been possible without Hank’s idea and without support from the Schueler family.”

And note the importance that is given to this discovery for other children:

“Identification of children with low-hypodiploid ALL and inherited TP53 mutations could help expand the use of life-saving cancer screening,” said Linda Holmfeldt, Ph.D., a St. Jude postdoctoral fellow. She and Lei Wei, Ph.D., of the St. Jude Department of Computational Biology and formerly of Pathology, are the study’s co-first authors. “Screening helps save lives by finding cancers much earlier when the odds of a cure are greatest,” Holmfeldt said.

And these findings and the potential screening benefits for other children would not have been possible with the generous love and support from all of you that are reading this newsletter. Thanks for your support.

We are continuing to support this study at St. Jude’s. The Foundation has agreed to fund a two-year clinical research technician position (the “Henry Schueler 41 & 9 Senior Research Technologist”) at St. Jude’s where they will assist senior researchers Dr. Mullighan and Linda Holmfeldt, Ph.D. as they conduct future studies that will provide new insights into the induction and development of leukemia and identify new therapeutic strategies for Hypodiploid ALL. St. Jude’s has hired Roberta Marino to their team studying “HALL”. A short bio follows. We welcome Roberta to this important position and the 41 & 9 family!

Roberta Marino: A native of Brazil, Roberta obtained her B.S. in 2001 in Biological Sciences at Mackenzie Presbyterian University, São Paulo. She graduated with a Master of Science degree in 2004 from the Federal University of São Paulo with work focusing on mesenchymal stem cell (MSC) therapy geared towards cures for neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis (Lou-Gehrig-Disease). Roberta obtained her Ph.D. in Biomedical Sciences in a joint program administered by the Federal University of São Paulo, Brazil, the University of Tennessee and St. Jude Children’s Research Hospital in Memphis, Tennessee. Roberta’s thesis was focused on bone marrow osteoprogenitors and their niche. She developed her first post-doctoral fellowship at The Children’s Hospital of Philadelphia where she joined the Department of Oncology to work with multipotent mesenchymal stromal cells as a vehicle for anti-tumor drugs. Her second post-doctoral fellowship was also at CHOP where she joined the Department of Neonatology and her main project was to evaluate the influence of certain growth factors on stress hematopoiesis. In October of 2011 she accepted a position as a research associate at the University of Wisconsin-Madison. Her research was focused on the evaluation of a novel phospholipid-ether compound in pediatric (e.g. neuroblastoma) and adult cancer (e.g. multiple myeloma). The compound can be used for simultaneous tumor imaging and cancer therapy.

*Footnote: The Children’s Oncology Group: The Children’s Oncology Group (www.childrensoncologygroup.org) is the world’s largest organization devoted exclusively to childhood and adolescent cancer research. The Children’s Oncology Group (COG) unites more than 8,000 experts in childhood cancer at more than 200 leading children’s hospitals, universities, and cancer centers across North America, Australia, New Zealand, and parts of Europe in the fight against childhood cancer. Today, more than 90 percent of the 13,500 children and adolescents diagnosed with cancer each year in the United States are cared for at COG member institutions. Research performed by the Children’s Oncology Group institutions over the past fifty years has transformed childhood cancer from a virtually incurable disease to one with a combined 5-year survival rate of 80 percent. COG’s mission is to improve the cure rate and outcome for all children with cancer. 

Make A Donation –>

Progress Regarding Zygomycosis (Mucormycosis)

 

Zygomycosis, also known as mucormycosis, is a disease that attacks cancer patients like Hank and others when their host defenses are compromised by treatment. Though Hank’s leukemia had resurfaced following his bone marrow transplant in September, 2007 it was this deadly fungal infection which eventually robbed him of his eyesight and ultimately took his life in December of 2007. Through your generosity the Foundation was able to publish in 2012 (Oxford University Press) a medical and scientific supplement on Zygomycosis which reached almost 12,000 medical subscribers worldwide. Our Foundation sponsored the conference which generated this research and then paid for its subsequent publication after its acceptance by the prestigious journal, Clinical Infectious Disease (“CID”). It is entitled “Advances Against Mucormycosis: A Tribute to the Memory and Courage of Hank Schueler”.

This Supplement was edited by Dr. Thomas Walsh, the Director of the new Transplantation-Oncology Infectious Diseases Program at Cornell University Medical Center (Weill-Cornell Medical College and New York Presbyterian Hospital) in New York. It is widely held as the most comprehensive and authoritative body of research on the subject of mucormycosis in the world.

Shortly after its publication, Dr. Walsh wrote a note to the Study’s authors and members of the Henry Schueler Foundation Board:

Dear Co-authors and Members of the Board of the Henry Schueler 41& 9 Foundation,

Enclosed is the complete publication of our work, “Advances Against Mucormycosis: A Tribute to the Memory and Courage of Hank Schueler.” This CID Supplement is available in the public domain through your expertise and generosity to serve as a powerful resource to guide the management and research of mucormycosis. I thank you for your dedication, knowledge and compassion in honoring the memory of Hank and in securing a better future for our patients who will battle this terrible infection.

In 2013, Dr. Walsh was also named as the Henry Schueler 41 & 9 Foundation Scholar. This title accompanies all of his correspondence, manuscripts, and other publications and confers greater public awareness of the Henry Schueler 41 & 9 Foundation and assists Dr. Walsh in pursuing the Foundation’s mission in mucormycosis. His Mission and ours is to develop new strategies for diagnosis, treatment, and prevention of invasive mucormycosis., increase public awareness of the epidemiology, morbidity and mortality of invasive mucormycosis., and to provide expert outreach assistance to patients with mucormycosis, their families, and their physicians. 

In May of 2013, Dr. Walsh gave the Inaugural Henry Schueler 41 & 9 Foundation Scholar Lecture on Mucormycosis at Northwestern. The event was chaired by Dr. John Flaherty, a Sauganash resident, who serves as Professor of Medicine and Associate Chief, Division of Infectious Diseases at Northwestern University Feinberg School of Medicine.

The turnout was excellent and discussion afterward was enthusiastic. The Lecture served as an important benchmark for our past achievements and future plans. 

Make A Donation –>

Advances Against Mucormycosis: A Tribute to the Memory and Courage of Hank Schueler

 

Clinical Infectious Diseases: Volume 54 suppl 1 February 1, 2012

Click here to read

41&9 Foundation®. Theme Meizitang

buy cheap viagra online
generic-viagra
buy online order viagra
buy now viagra
free viagra sample
buy generic viagra usa
buy viagra pills
viagra and cialis cheap
buy get online prescription viagra
viagra super active
buy viagra online without prescription
buy discount cialis
ed pro trial pack
buy real viagra online
cheap generic india viagra
viagrafree samples
online overnight viagra
viagra price in india
cheap viagra tablets
buy cialis online
buy online online viagra viagra
buy viagra online in the uk
cheap sale viagra
cheap generic 50 mg viagra
marijuana and viagra
levitra 100mg uk
cheap meltabs online viagra
free viagra
buy viagra pharmacy online
cheap pill pill sale viagra
buy cheap tamiflu
buy viagra cheaply
ordering viagra onl
cheap phizer viagra
cheap generic viagra overnight delivery
viagra and cialis
cialis super active review
where to buy viagra in beijing
buy cheap viagra online uk
buy prescription viagra
cheap generic viagra uk
buy viagra online au
cheap discount levitra online
buy real viagra online pharmacy
cheap viagra without a prescription
buy now levitra
buy viagra online online pharmacy
cheap viagra generic
accutane for sale online
buy viagra onli
buy cheap viagra
buy viagra per pill
viagra rrp australia cost
buy sildenafil viagra
viagra coupons and discounts
price of viagra
cipro 20
cheap herbal viagra viagra
levitra online
cheap free viagra viagra
cheap levitra online
buy viagra online
Viagra for sale
buy viagra online pharmacy
buy viagra online at lowest price
viagra over the counter walgreens
buy viagra online no prescription
cheap inexpensive viagra
buy 100 mg viagra
buying viagra
buy viagra online in australia
female viagra
cheap kamagra viagra
buy nexium
cheap generic viagra worcester imc
buy generic viagra buy
which is better cialis or viagra
discount viagra
buy generic viagra online
cost of viagra
buy viagra online get prescription
buy in spain viagra
buy real viagra
buy site viagra
cialis no perscription
cialis voucher
buy real viagra pharmacy online
buy discounted viagra
viagra dosage
cheap cialis overnight
buy viagra online paypal vipps
generic cialis
buy cialis from india
cialis no prescription
buy female viagra
buy viagra 50mg
buy online drug viagra pharmacy
generic viagra
how can i buy viagra online in canada
cheap generic viagra from usa
buy viagra online u
cheap drugs viagra cialas
cheap mexico viagra
buy generic viagra viagra
buy levitra now
india viagra cialis vicodin
viagra suppliers in the uk
viagra online uk
buy viagra online australia
cheap generic viagra
viagra uk cheap purchase buy
buy line viagra
cheapest uk supplier viagra
cheap generic viagra no script
buy viagra online cheapest
buy discount viagra
key buy-viagra
buying viagra online
buy price viagra
purchase levitra
cheap site viagra
buy viagra online uk
buy viagra and cilas
cheap deal viagra
buy viagra prescription
buy viagra other drug online
viagra alternatives
viagra sample
buy generic viagra
where can I buy cialis 20mg
buy generic viagra pharmacy online
buy internet viagra
brand cialis 20
buy viagra online paypal
buy viagra overnight
buy viagra online
shipping viagra to australia
buy kamagra viagra india
non prescription viagra
cheap generic overnight viagra
brand cialis
buy viagra cialis
purchase levitra online
buy levitra canada
buy lexapro
buy low price viagra
buy cheap cialis
buy viagra online canadapurchase cialis
buy levitra viagra online
buy kamagra viagra
buy viagra online order
cheap generic viagra substitute
buy discount viagra viagra viagra
ebay + cialis
buy prescription vaniqa viagra
cheap viagra in the uk
cheap prescription viagra without
cialis vs viagra
guaranteed cheapest viagra
buy viagra montreal
buy later now pay viagra
buy cheap viagra online
buy viagra online ireland
buy viagra online alternative viagra
viagra without prescription
free viagra without prescription
buy viagra online
does watermelon have viagra effect
buy viagra cheapest best prices online
buy generic viagra
buy now online viagra
cheap pill viagra
cheap viagra india
buy viagra online now buy viagra
buy viagra online at
alternative to viagra
cheap generic online viagra
viagra for sale
cheap herbal viagra
buy line viagra where
over the counter viagra
buy viagra online off pharmacy prices
cheap no prescription viagra
buy viagra pill
viagra and cialis and
is viagra safe for women
cheap kamagra uk viagra
purchase viagra online
cheap pharmacy viagra
buy viagra cialis levitra
buy viagra over the counter
buy internet viagra
cheap free viagra
buy viagra online at cheap price
buy viagra prescription america
cheap viagra in uk
uninsured cost of cialis
natural viagra
viagra oral jelly
buy viagra online a href
buy cialis canada
buy viagra now
cheap viagra
ed. trusted medstore in cialis
uk viagra sales
buy viagra pill online
buy in uk viagra
cheap man viagra
viagra and hearing loss
cheap generic viagra substitutes
viagra professional
buy viagra online order generic viagra
cheap viagra fast shipping
cheap price viagra
cheap generic viagra online
walmart cialis price
cialis replacement
Viagra Oklahoma city
free viagra in the uk
buy now cialis
buy generic viagra img
buy viagra on the internet
generic viagra from india
cheap cialis online
cheap prescription viagra
buy viagra
cheap discount viagra viagra
buy online online pill viagra viagra
buy generic viagra online pharmacy online
buy viagra internet
buy sale viagra
cheap meltabs viagra
buy no online prescription viagra
viagra oral
cheap molde ticket viagra
cheap pharmaceutical viagra
buy in online usa viagra
cheap india viagra
cheap soft tab viagra
viagra uk
cialis coupons
buy cialis now
cheap generic viagra no prescription
cheap viagra online canada
buy online levitra cialis viagra
buy viagra online in
amazon viagra
viagra pfizer
buy viagra usa
buy viagra onlines
buy discount soma
lowest price viagra
viagra rrp australia
female use of viagra
cialis overnight shipping
buy viagra online in uk
buy viagra over the counter us
buy viagra cheapest
buy cialis no prescription
buy in online uk viagra
ordering cialias
cheap discount viagra